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Antimicrobial Peptides:

Antimicrobial Peptides:

Edited by G Wang

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£94.95
Antimicrobial Peptides:

Antimicrobial Peptides (AMPs) are an organism's built-in defence molecules that have attracted extensive research attention worldwide. Harnessing and creating them synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. In addition to covering the current advances in AMP research, this volume examines new technologies such as bioinformatics, combinatorial libraries, high-throughput screening, peptidomimetics, biophysics, and structural biology. This volume also describes new methods and strategies for AMP prediction, design, and applications that overcome obstacles in developing them into therapeutic agents.

Readership

Researchers, microbiologists, medical and industrial personnel.

Additional Information

Author Edited by G Wang
Availability In Print
Dimensions Unknown
Extent 240 Pages
ISBN 9781845936570
Publication date Nov-10
Book Type Hardcover

Contents

Preface

Introduction

Part I: Natural Antimicrobial Peptides: Nomenclature, Classification, and Interesting Templates for Peptide Engineering

1. A Database View of Naturally Occurring Antimicrobial Peptides: Nomenclature, Classification and Amino Acid Sequence Analysis

2. Lantibiotic-related Research and the Application thereof

3. Antimicrobial Peptides in Plants

Part II: Expanding the Peptide Space: Prediction Methods, Design Strategies, and Peptidomimetics

4. Database-aided Prediction and Design of Novel Antimicrobial Peptides

5. Discovery of Novel Antimicrobial Peptides Using Combinatorial Chemistry and High-Throughput Screening

6. Chemical Mimics with Systemic Efficacy

Part III: Biophysics, Structural Biology and Mechanism of Action of Antimicrobial Peptides

7. Biophysical Analysis of Membrane-Targeting Antimicrobial Peptides: Membrane Properties and the Design of Peptides Specifically Targeting Gram-negative Bacteria

8. Non-membrane Targets of Antimicrobial Peptides: Novel Therapeutic Opportunities?

9. Structural Studies of Antimicrobial Peptides Provide Insight into Their Mechanisms of Action

Part IV: Novel Therapeutic Strategies to Bolster Host Defence

10. Lung Infection: Shifting the Equilibrium toward the Free and Active Form of Human LL-37 and the Design of Alternative Antimicrobial Agents

11. Role of Vitamin D in the Enhancement of Antimicrobial Peptide Gene Expression

12. Fine Tuning Host Responses in the Face of Infection: Emerging Roles and Clinical Applications of Host Defence Peptides

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